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WH 018 (exempt preparation) (Item No. 13169) is an analytical reference standard categorized as a synthetic cannabinoid.1 JWH 018 has been found in Spice/K2-type herbal blends and may have neurotoxic properties. JWH 018 is regulated as a Schedule I compound in the United States. JWH 018 (exempt preparation) (Item No. 13169) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.

Abstract: 3-(1-Naphthalenylmethyl)-1-pentyl-1H-indole (JWH-175) is a synthetic cannabinoid il-
legally marketed for its psychoactive cannabis-like effects. This study aimed to investigate and
compare in vitro and in vivo pharmacodynamic activity of JWH-175 with that of 1-naphthalenyl
(1-pentyl-1H-indol-3-yl)-methanone (JWH-018), as well as evaluate the in vitro (human liver micro-
somes) and in vivo (urine and plasma of CD-1 male mice) metabolic profile of JWH-175. In vitro
binding studies showed that JWH-175 is a cannabinoid receptor agonist less potent than JWH-018 on
mouse and human CB1 and CB2 receptors. In agreement with in vitro data, JWH-175 reduced the
fESPS in brain hippocampal slices of mice less effectively than JWH-018. Similarly, in vivo behavioral
studies showed that JWH-175 impaired sensorimotor responses, reduced breath rate and motor
activity, and increased pain threshold to mechanical stimuli less potently than JWH-018. Metabolic
studies demonstrated that JWH-175 is rapidly bioactivated to JWH-018 in mice blood, suggesting that
in vivo effects of JWH-175 are also due to JWH-018 formation. The pharmaco-toxicological profile of
JWH-175 was characterized for the first time, proving its in vivo bio-activation to the more potent
agonist JWH-018. Thus, it highlighted the great importance of investigating the in vivo metabolism
of synthetic cannabinoids for both clinical toxicology and forensic purposes.
  • AM678
Technical Information
Formal Name
CAS Number
Molecular Formula
Formula Weight
A solution in methanol
  • DMF: 10 mg/ml
  • DMSO: 10 mg/ml
  • Ethanol: 10 mg/ml
  • Methanol: 30 mg/ml
219, 246, 315 nm
InChi Code
InChi Key
DEA Exempt Notification
This product is a DEA exempt preparation of a scheduled compound – no special processing required. For larger quantities or alternate sizes please contact sales.
Shipping & Storage Information
Room Temperature in continental US; may vary elsewhere
≥ 1 year


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